By Yin-Tak Woo, David Y. Lai, Joseph C. Arcos
Chemical Induction of melanoma: Structural Bases and organic Mechanisms, quantity IIIB: Aliphatic and Polyhalogenated cancer causing agents covers environmentally and occupationally major cancer agents of commercial origins.
The ebook discusses the structure-activity relationships, metabolism, and environmental value of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene insecticides, biphenyls, and comparable aromatics. The textual content additionally describes the structure-activity relationships, metabolism, and environmental importance of the halogenated phenoxy acids, fragrant ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and similar compounds. The structure-activity relationships, metabolism, and environmental value of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and similar compounds thiocarbonyl compounds also are encompassed. The ebook additional tackles the structure-activity relationships, metabolism, and environmental value if fatty acids, detergents, and different surfactants with oncogenic power. The textual content then appears to be like into the influence of chemical reactivity, molecular geometry, and metabolism on carcinogenic job.
Chemists, geneticists, and people all for melanoma learn will locate the booklet valuable.
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Extra resources for Aliphatic and Polyhalogenated Carcinogens. Structural Bases and Biological Mechanisms
The vinylic-type compound, 2-chloro-2-butene, may be metabolically activated, whereas 4-chloro-l-butène is inactive even in the presence of the S9 system. No good correlation between mutagenicity and alkylating activity of the four halobutenes and halobutadienes was observed by Bartsch et al. (74). The relative potencies follow the order: 3,4-dichloro-l-butène > 1,4-dichloro-2-butene > 1chlorobutadiene > 2-chlorobutadiene (without metabolic activation). 3,4-Dichloro-1-butène has a very weak alkylating activity in the NBP reaction, whereas 1,4-dichloro-2-butene and 1-chlorobutadiene are very strong alkylating agents.
Among halomethanes, dichloromethane (méthylène chloride), chloroform, and carbon tetrachloride have been tested. Dichloromethane has been assayed in Sprague-Dawley rats and Swiss Webster mice by Schweiz et al. (193) and in Long-Evans rats by Hardin and Manson (194). In the former investigation rodents were exposed to an atmosphere containing 1250 ppm dichloromethane for 7 h/day on days 6-15 of gestation, whereas in the latter study rats were exposed to 4500 ppm 6 h/day before and during gestation.
The teratogenicity of halothane (l,l,l-trifluoro-2-bromo-2-chloroethane) has been extensively studied. 1 Halogenated Linear Alkanes and Alkenes I 29 (12 h) on various days of gestation. Significant increases in the incidence of skeletal malformations were observed following exposure on days 8 and 9 of gestation. 5%) during organogenesis were teratogenic in C57B1 mice inducing cleft palate, limb hematomas, and ossification defects (204). 30% for rabbits) of halothane on days 1-5, 6-10, or 11-15 of gestation did not bring about significant teratogenic effects (205).