By Guy B. Faguet
After a fascinating in-depth old point of view, this booklet studies fresh clinical advances in molecular genetics and biology of continual lymphocytic leukemia, and discusses scientific features of the disorder, concentrating on analysis, analysis, remedies, and issues. a last bankruptcy addresses familial and juvenile instances. DNLM: Leukemia, Lymphocytic, persistent.
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Extra info for Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management (Contemporary Hematology)
Cytogenetics In 1914, Boveri (133) described chromosomal changes in tumor cells. In 1960, Nowell and Hungerford (134) identified the first tumor-specific chromosomal abnormality, the Philadelphia (Ph) chromosome, a minute chromosome in chronic myeloid leukemia. After the development of chromosome banding Caspersson et al. (135,136) identified the Ph chromosome as an abbreviated chromosome 22. When chromosome banding became available, the chromosomes were enumerated from 1 (the largest) to 22 (the shortest).
The sex chromosomes were designated X and Y. The shortest arm of the chromosome is designated p (shown above the centromere in figures), and the long arm is termed q. Differences in the number of copies were presented with a minus sign for monosomy and a plus for trisomy. Other abnormalities are indicated by letters. The chromosomes involved in the abnormality are placed in parentheses in numerical order separated by a semicolon (;). Following in a second parentheses are the specific breakpoint bands for each chromosome, also separated by a semicolon.
Survival curves for 145 patients with B-CLL from date of diagnosis, comparing patients whose cells are CD38+ and who have unmutated IgVH genes (n = 34), with those whose cells are CD38– and who have mutated IgVH genes (n = 70) and those whose cells gave discordant results for the two assays (n = 41). (From ref. , 2002, Fig. 5. ) In the initial report by Damle et al. (104,105), a correlation was shown with Ig gene sequence and CD38 expression. Those CLL patients with 30% or more lymphocytes positive for CD38 expression were also found to have the germline configuration.