Download Comprehensive Enantioselective Organocatalysis: Catalysts, by Peter I. Dalko PDF

By Peter I. Dalko

A much-needed evaluation reflecting the advancements during the last 5 years, this is often the main accomplished instruction manual on organocatalysis. As such, all suitable catalyst structures are mentioned intimately, in addition to key techniques, response kinds, and critical purposes in overall synthesis. the 1st volumes hide catalyst buildings and fundamental activation kinds. those chapters permit readers to familiarize themselves with the quite complicated interactions that make organocatalytic reactions selective; to realize an perception into the most productive catalyst forms; and to appreciate the significance of actual parameters that impression reactivity and selectivity. quantity 3 is based round response forms, i.e. nucleophile additions to C=X and C=C bonds; Friedel-Crafts reactions, organocatalytic sigmatropic reactions, regioselective reactions and desymmetrization innovations, ring-forming reactions, multicomponent (domino) reactions, multicatalyst structures and the applying of organocatalytic reactions in multistep synthesis are mentioned. An appendix recollecting catalyst buildings with the sufficient cross-references to the corresponding chapters rounds off the book.
With its contributions written by means of pioneers of the organocatalysis box, this publication presents non-specialists with an advent to the subject in addition to serving as a invaluable resource for researchers in academia and trying to find an up to date and entire evaluation of this promising region of artificial natural chemistry

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Additional resources for Comprehensive Enantioselective Organocatalysis: Catalysts, Reactions, and Applications

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6 Representative examples of proline-based heterocyclic organocatalysts. As a different family of heteroaromatic-substituted organocatalysts, imidazoleand triazole-based compounds have been known to be quite effective for asymmetric aldol and Michael addition reactions. 6 lists representative examples of these catalysts. The utility of ionic liquid conjugate catalysts such as 32 and 33 can be ascribed to their recyclability [195–199]. On the other hand, triazole-based catalysts such as 34 and 35 are readily accessible via Huisgen 1,3-dipolar cycloadditions, so-called “click reactions,” from azidomethyl-pyrrolidine and acetylenic precursors, and hence make it possible to design new immobilized catalysts [200–207].

2 Prolinamide and Related Catalysts Owing to the ready availability of prolinamide derivatives through the condensation of proline with amines, prolinamide-based compounds constitute a large family of organocatalysts [4]. 3 lists representative examples of these catalysts. Comprehensive Enantioselective Organocatalysis: Catalysts, Reactions, and Applications, First Edition. Edited by Peter I. Dalko. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2013 by Wiley-VCH Verlag GmbH & Co. KGaA. 1 Major classes of proline-based organocatalysts.

6 lists representative examples of these catalysts. The utility of ionic liquid conjugate catalysts such as 32 and 33 can be ascribed to their recyclability [195–199]. On the other hand, triazole-based catalysts such as 34 and 35 are readily accessible via Huisgen 1,3-dipolar cycloadditions, so-called “click reactions,” from azidomethyl-pyrrolidine and acetylenic precursors, and hence make it possible to design new immobilized catalysts [200–207]. 13) [208]. 1) can be envisaged as a reversal of prolinamides (A), and constitute a fascinating group of organocatalysts.

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