By Yusuke Ohta
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles through catalytic domino response together with multi-component coupling was once built, and is the 1st instance of a three-component indole formation with out generating salts as a byproduct. according to this response, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline used to be comprehensive which represents an exceptional isoquinoline synthesis via a four-component coupling response. Following those effects, broad software reviews utilizing one-pot palladium-, acid-, or base-promoted cyclization published that indole- or isoquinoline-fused polycyclic compounds might be effortlessly synthesized via multi-component reactions. because the thought of eco-friendly Chemistry turns into ever extra very important, those findings could provide effective and atom-economical techniques to the diversity-oriented synthesis of bioactive compounds containing a fancy constitution. this may bring about improvement of promising drug leads with structural complexity. The paintings of this thesis will cross directly to encourage the factitious examine of many readers.
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Extra resources for Copper-Catalyzed Multi-Component Reactions: Synthesis of Nitrogen-Containing Polycyclic Compounds
2114. 1052. 010 mmol) at rt under argon. 18 mmol) were successively added and the reaction mixture was additionally stirred for 5 d at rt. 00, CHCl3). 1665. 1859. 2099. 1672. 2007. 0900. 0775. 0957. 1051. 0771. 0947. 1065. 5 h under argon. 1804. 1671. 1854. 1953. 1665. 1839. 19 mmol) in DMA (2 mL) was stirred at 140 °C for 1 h under argon. 1952. 42 mmol) at rt. The mixture was stirred for 7 h at this temperature, and the whole was extracted with CHCl3. The extract was washed with H2O and dried over MgSO4.
The whole was extracted with Et2O. The extract was washed successively with 1 N HCl and brine, and dried over MgSO4. 8. Anal. 29. 25. 90 mmol) was converted into S10c (722 mg, 73%) as an yellow oil. 6. Anal. 16. 27. 5 mmol). 43 g, 97%).
0771. 0947. 1065. 5 h under argon. 1804. 1671. 1854. 1953. 1665. 1839. 19 mmol) in DMA (2 mL) was stirred at 140 °C for 1 h under argon. 1952. 42 mmol) at rt. The mixture was stirred for 7 h at this temperature, and the whole was extracted with CHCl3. The extract was washed with H2O and dried over MgSO4. 1443. 2108. 38 mmol) in CH2Cl2 (1 mL) at rt under argon. The reaction mixture was stirred at 40 °C for 1 h, and the whole was extracted with CHCl3. The extract was washed successively with Na2CO3 and H2O.