Download Copper-Catalyzed Multi-Component Reactions: Synthesis of by Yusuke Ohta PDF

By Yusuke Ohta

A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles through catalytic domino response together with multi-component coupling was once built, and is the 1st instance of a three-component indole formation with out generating salts as a byproduct. according to this response, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline used to be comprehensive which represents an exceptional isoquinoline synthesis via a four-component coupling response. Following those effects, broad software reviews utilizing one-pot palladium-, acid-, or base-promoted cyclization published that indole- or isoquinoline-fused polycyclic compounds might be effortlessly synthesized via multi-component reactions. because the thought of eco-friendly Chemistry turns into ever extra very important, those findings could provide effective and atom-economical techniques to the diversity-oriented synthesis of bioactive compounds containing a fancy constitution. this may bring about improvement of promising drug leads with structural complexity. The paintings of this thesis will cross directly to encourage the factitious examine of many readers.

Show description

Read or Download Copper-Catalyzed Multi-Component Reactions: Synthesis of Nitrogen-Containing Polycyclic Compounds PDF

Best applied mathematicsematics books

Genocide: A Comprehensive Introduction, Second Edition

A useful creation to the topic of genocide, explaining its heritage from pre-modern occasions to the current day, with a large choice of case reports. fresh occasions within the former Yugoslavia, Rwanda, East Timor and Iraq have tested with appalling readability that the specter of genocide continues to be a big factor inside international politics.

Frommer's Hong Kong (2009) (Frommer's Complete) 10th Edition

America’s no 1 bestselling shuttle sequence Written by means of greater than one hundred seventy five outspoken tourists world wide, Frommer’s whole publications aid tourists event locations the best way locals do. extra each year up to date courses than the other sequence 16-page colour part and foldout map in all annual publications Outspoken critiques, specified costs, and prompt itineraries Dozens of particular maps in an easy-to-read, two-color layout

Lifetimes of Fluorinated Compounds

Fee constants for reactions of eleven hydrochlorofluorocarbons and 12 hydrofluorocarbons have been measured by way of absolutely the expense approach over the temperature variety 250-430 ok. OH radicals have been generated by way of flash photolysis, laser photolysis, or a discharge circulate tools; and the focus of OH radicals was once monitored by way of the laser-induced fluorescence process.

Extra resources for Copper-Catalyzed Multi-Component Reactions: Synthesis of Nitrogen-Containing Polycyclic Compounds

Example text

2114. 1052. 010 mmol) at rt under argon. 18 mmol) were successively added and the reaction mixture was additionally stirred for 5 d at rt. 00, CHCl3). 1665. 1859. 2099. 1672. 2007. 0900. 0775. 0957. 1051. 0771. 0947. 1065. 5 h under argon. 1804. 1671. 1854. 1953. 1665. 1839. 19 mmol) in DMA (2 mL) was stirred at 140 °C for 1 h under argon. 1952. 42 mmol) at rt. The mixture was stirred for 7 h at this temperature, and the whole was extracted with CHCl3. The extract was washed with H2O and dried over MgSO4.

The whole was extracted with Et2O. The extract was washed successively with 1 N HCl and brine, and dried over MgSO4. 8. Anal. 29. 25. 90 mmol) was converted into S10c (722 mg, 73%) as an yellow oil. 6. Anal. 16. 27. 5 mmol). 43 g, 97%).

0771. 0947. 1065. 5 h under argon. 1804. 1671. 1854. 1953. 1665. 1839. 19 mmol) in DMA (2 mL) was stirred at 140 °C for 1 h under argon. 1952. 42 mmol) at rt. The mixture was stirred for 7 h at this temperature, and the whole was extracted with CHCl3. The extract was washed with H2O and dried over MgSO4. 1443. 2108. 38 mmol) in CH2Cl2 (1 mL) at rt under argon. The reaction mixture was stirred at 40 °C for 1 h, and the whole was extracted with CHCl3. The extract was washed successively with Na2CO3 and H2O.

Download PDF sample

Rated 4.68 of 5 – based on 19 votes